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Comprehensive Antibiotic Resistance Database
The Antibiotic Resistance Database documents antibiotic resistance information and an ontology that is undergoing ongoing revisions.
About Comprehensive Antibiotic Resistance Database
The Comprehensive Antibiotic Resistance Database (CARD) is a bioinformatic database of resistance genes, their products and associated phenotypes. It contains characterized, peer-reviewed resistance determinants and associated antibiotics, organized by the Antibiotic Resistance Ontology (ARO) and AMR gene detection models. The site notes that the ARO undergoes ongoing revisions.
Users can browse CARD and the ARO, and use the Resistance Gene Identifier (RGI) to predict resistomes from protein, genome, genome assembly data, or metagenomic sequencing reads. The site also provides tools to visualize results and predict pathogen-of-origin, with options to run analyses on the web or download the software for local use. Additional sections cover computer-generated resistome predictions, Mycobacterium tuberculosis mutations, fungal mutations, literature-derived epidemiology associations, and a bait capture method for metagenomic detection.
Data, ontologies, sequences and protocols can be downloaded in several formats with metadata and citations. The resource suits researchers, clinicians and students working with antimicrobial resistance genes, genomes and surveillance data who need curated reference information and sequence analysis tools.
Key features
- Browse resistance genes organized by Antibiotic Resistance Ontology
- Predict resistomes from genomes and metagenomic reads with RGI
- Run RGI on web or as downloadable command-line tool
- Download data, ontologies, mutations and protocols with citations
- Search M. tuberculosis mutations from ReSeqTB, CRyPTIC, WHO catalogs
- View computer-generated resistome predictions for 414 pathogens
Best for: Researchers and students analyzing genomes and metagenomes for antibiotic resistance genes benefit most.
Good for
- Curated peer-reviewed resistance determinants with citations
- Web and local options for RGI analysis
- Downloadable data, ontologies and protocols
- Includes TB mutations, fungal data and epidemiology associations
Watch out for
- ARO revisions may affect downstream analyses
- FungAMR integration to CARD and ARO is in progress
Comprehensive Antibiotic Resistance Database at a glance
- Website
- card.mcmaster.ca
- Category
- Research & Data › Health & Medical Data
- Type
- Website
- Pricing
- Not confirmed. Check the site
- Platforms
- Web
- Open source
- Not stated
- Last checked
- Oct 5, 2026 · Online when checked
- Listed
- Oct 5, 2026
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Comprehensive Antibiotic Resistance Database FAQ
What is CARD?
CARD is a bioinformatic database of resistance genes, their products and associated phenotypes, organized by the Antibiotic Resistance Ontology and AMR detection models.
What does the Resistance Gene Identifier do?
RGI predicts resistomes from protein, genome, genome assembly data, or metagenomic sequencing reads. Results can be visualized and used for pathogen-of-origin prediction on the web or locally.
Can CARD data be downloaded?
Yes. CARD data, ontologies, mutation and molecule lists, RGI software, and bait capture sequences and protocols are available for download with metadata and citations.
Does CARD include tuberculosis mutations?
Yes. It provides a searchable list of Mycobacterium tuberculosis mutations conferring AMR compiled from the ReSeqTB, CRyPTIC, and World Health Organization catalogs.
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