Search BioGRID ORCS, an open database of curated CRISPR screen records.

orcs.thebiogrid.org
BioGRID ORCS homepage screenshot

About BioGRID ORCS

BioGRID ORCS is an open repository of CRISPR screen records compiled through curation of published literature. Its homepage states that the current index (version 2.0.18) covers 418 publications and 94,219 genes, returning 2,217 CRISPR screens from 5 model organism species, 825 cell lines, and 145 cell types. Users can search the index and download the screen data in several standardized formats.

The data are also available through the BioGRID ORCS REST web service over HTTPS, which can be used programmatically or in a browser. BioGRID ORCS is a separate resource from the broader BioGRID interaction repository, which the homepage describes as covering interaction, post-translational modification, and chemical association data.

Key features

  • Search index of curated CRISPR screen records from published studies
  • Browse screens by curation project, such as coronavirus, Fanconi anemia, and glioblastoma
  • Download screen data in multiple standardized formats
  • REST web service over HTTPS for programmatic access to screen data
  • Themed curation projects focused on disease-relevant biological processes, updated monthly
Best for: Researchers and data users who need to search, download, or retrieve curated CRISPR screen data, including through programmatic access.
Good for
  • All screen data are stated to be freely provided through the search index
  • Data are available for download in a range of standardized formats
  • Programmatic access is available through the REST web service

BioGRID ORCS at a glance

Official website
orcs.thebiogrid.org
Type
Dataset
Platforms
Web
Language
English
Last checked
Oct 6, 2026 · Online when checked
Listed
Oct 5, 2026

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BioGRID ORCS FAQ

Is the screen data free to access?
The homepage states that all screen data are freely provided through the search index and available via download in a wide variety of standardized formats.
How can screen data be retrieved programmatically?
CRISPR screen data can be accessed through the BioGRID ORCS REST web service over HTTPS, either programmatically or in a browser.
How often are the themed curation projects updated?
The homepage states that themed curation projects are updated monthly, and additional projects are added on a regular basis.
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