OrtholugeDB

OrtholugeDB provides orthology predictions for sequenced bacterial and archaeal genomes, using Ortholuge and reciprocal best-hit methods.

ortholugedb.ca
OrtholugeDB homepage screenshot

About OrtholugeDB

OrtholugeDB contains orthology predictions for completely sequenced bacterial and archaeal genomes. It includes Ortholuge-based predictions, reciprocal best-hit-based predictions, in-paralog predictions for recently duplicated genes, and proposed ortholog groups. The current version is Release 2.1.

Users can compare presence or absence of orthologs across multiple genomes from a reference genome, obtain orthologs between two genomes with optional unique-gene results and local gene context, or retrieve orthologs for a single gene by ID or name with strain filtering.

Key features

  • Ortholuge-based orthology predictions for bacterial and archaeal genomes
  • Reciprocal best-hit-based ortholog predictions
  • In-paralog predictions for recently duplicated genes
  • Proposed ortholog groups
  • Two-genome comparison with unique-gene option and local gene context
  • Single-gene ortholog lookup by ID or name with strain filtering
Best for: Researchers working with completely sequenced bacterial and archaeal genomes who need ortholog predictions.
Good for
  • Provides both Ortholuge-based and reciprocal best-hit-based predictions
  • Supports single-gene, two-genome, and multi-genome queries
  • Shows local gene context for orthologs
Watch out for
  • Limited to completely sequenced bacterial and archaeal genomes

OrtholugeDB at a glance

Type
Website
Pricing
Not confirmed. Check the site
Platforms
Web
Open source
Not stated
Last checked
Oct 5, 2026 · Online when checked
Listed
Oct 5, 2026

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