UniProtKB/Swiss-Prot is the reviewed section of UniProtKB, with manually annotated protein sequences and experimental information.
SWISS-MODEL Repository
The SWISS-MODEL Repository contains annotated 3D protein structure models generated by a homology-modelling pipeline.
About SWISS-MODEL Repository
The SWISS-MODEL Repository provides annotated 3D protein structure models generated by automated homology modelling, plus experimental PDB structures mapped to UniProtKB sequences. Users can search by UniProtKB accession, entry name, or free-text protein name, and assess models using QMEAN results.
It contains 3,779,347 homology models and 244,563 mapped PDB structures, with homology models focused on reference proteomes of listed model organisms based on UniProtKB release 2026_03. Sequences without a model can be built in the SWISS-MODEL workspace, and users who want to download a large number of models are asked to contact the provider.
Key features
- Search models by UniProtKB accession or entry name
- Search by free-text protein names
- View annotated 3D homology models and PDB structures mapped to UniProtKB
- Assess model quality with QMEAN results
- Build missing models via SWISS-MODEL workspace
- Download model coordinates and metadata for reference proteomes
Best for: Researchers who need annotated 3D protein models for UniProtKB sequences and reference proteomes.
Good for
- Contains 3,779,347 homology models and 244,563 mapped PDB structures
- Regularly updated using recent sequence and template structure databases
- Provides QMEAN results for assessing model quality
Watch out for
- Homology models cover reference proteomes of listed model organisms
- Downloading a large number of models requires contacting the provider
- Unmodelled sequences require building a model in the SWISS-MODEL workspace
SWISS-MODEL Repository at a glance
- Category
- Research & Data › Open Data & Datasets
- Type
- Website
- Pricing
- Not confirmed. Check the site
- Platforms
- Web
- Open source
- Not stated
- Language
- English
- Last checked
- Oct 5, 2026 · Online when checked
- Listed
- Oct 5, 2026
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SWISS-MODEL Repository FAQ
How do I search the repository?
Fetch by UniProtKB AC or entry name, or search using free text such as a protein name.
What can I do if my sequence has no model?
Build models interactively via the SWISS-MODEL workspace.
How do I download a large number of models?
Contact the provider, as requested for large downloads.
Is something wrong or out of date?
Tell us and an editor will check it.
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